Serotonin and dopamine transporter PET changes in the premotor phase of LRRK2 parkinsonism: cross-sectional studies.
Identifieur interne : 000029 ( Main/Exploration ); précédent : 000028; suivant : 000030Serotonin and dopamine transporter PET changes in the premotor phase of LRRK2 parkinsonism: cross-sectional studies.
Auteurs : Daryl J. Wile [Canada] ; Pankaj A. Agarwal [Inde] ; Michael Schulzer [Canada] ; Edwin Mak [Canada] ; Katherine Dinelle [Canada] ; Elham Shahinfard [Canada] ; Nasim Vafai [Canada] ; Kazuko Hasegawa [Japon] ; Jing Zhang [États-Unis] ; Jessamyn Mckenzie [Canada] ; Nicole Neilson [Canada] ; Audrey Strongosky [États-Unis] ; Ryan J. Uitti [États-Unis] ; Mark Guttman [Canada] ; Cyrus P. Zabetian [États-Unis] ; Yu-Shin Ding [États-Unis] ; Mike Adam [Canada] ; Jan Aasly [Norvège] ; Zbigniew K. Wszolek [États-Unis] ; Matthew Farrer [Canada] ; Vesna Sossi [Canada] ; A Jon Stoessl [Canada]Source :
- The Lancet. Neurology [ 1474-4465 ] ; 2017.
English descriptors
- KwdEn :
- Adult, Aged, Brain (metabolism), Cross-Sectional Studies, Dihydroxyphenylalanine (analogs & derivatives), Dopamine Plasma Membrane Transport Proteins (metabolism), Female, Heterozygote, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 (genetics), Male, Middle Aged, Mutation, Parkinson Disease (genetics), Parkinson Disease (metabolism), Positron-Emission Tomography (methods), Radiopharmaceuticals, Serotonin Plasma Membrane Transport Proteins (metabolism).
- MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- chemical , genetics : Leucine-Rich Repeat Serine-Threonine Protein Kinase-2.
- genetics : Parkinson Disease.
- metabolism : Brain, Dopamine Plasma Membrane Transport Proteins, Parkinson Disease, Serotonin Plasma Membrane Transport Proteins.
- methods : Positron-Emission Tomography.
- Adult, Aged, Cross-Sectional Studies, Female, Heterozygote, Humans, Male, Middle Aged, Mutation, Radiopharmaceuticals.
Abstract
People with Parkinson's disease can show premotor neurochemical changes in the dopaminergic and non-dopaminergic systems. Using PET, we assessed whether dopaminergic and serotonin transporter changes are similar in LRRK2 mutation carriers with Parkinson's disease and individuals with sporadic Parkinson's disease, and whether LRRK2 mutation carriers without motor symptoms show PET changes.
DOI: 10.1016/S1474-4422(17)30056-X
PubMed: 28336296
Affiliations:
- Canada, Inde, Japon, Norvège, États-Unis
- Floride, Trøndelag, Washington (État), État de New York
- Seattle, Trondheim
- Université de Washington
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Le document en format XML
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Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Neilson, Nicole" sort="Neilson, Nicole" uniqKey="Neilson N" first="Nicole" last="Neilson">Nicole Neilson</name><affiliation wicri:level="1"><nlm:affiliation>Pacific Parkinson's Research Centre, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Pacific Parkinson's Research Centre, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Strongosky, Audrey" sort="Strongosky, Audrey" uniqKey="Strongosky A" first="Audrey" last="Strongosky">Audrey Strongosky</name><affiliation wicri:level="2"><nlm:affiliation>Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Uitti, 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Wile</name><affiliation wicri:level="1"><nlm:affiliation>University of British Columbia, Department of Medicine, Vancouver, BC, Canada. Electronic address: dwile@mail.ubc.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of British Columbia, Department of Medicine, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Agarwal, Pankaj A" sort="Agarwal, Pankaj A" uniqKey="Agarwal P" first="Pankaj A" last="Agarwal">Pankaj A. Agarwal</name><affiliation wicri:level="1"><nlm:affiliation>Global Hospitals, Mumbai, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Global Hospitals, Mumbai</wicri:regionArea><wicri:noRegion>Mumbai</wicri:noRegion></affiliation></author><author><name sortKey="Schulzer, Michael" sort="Schulzer, Michael" uniqKey="Schulzer M" first="Michael" last="Schulzer">Michael Schulzer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Statistics, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Statistics, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Mak, Edwin" sort="Mak, Edwin" uniqKey="Mak E" first="Edwin" last="Mak">Edwin Mak</name><affiliation wicri:level="1"><nlm:affiliation>Pacific Parkinson's Research Centre, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Pacific Parkinson's Research Centre, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Dinelle, Katherine" sort="Dinelle, Katherine" uniqKey="Dinelle K" first="Katherine" last="Dinelle">Katherine Dinelle</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physics and Astronomy, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physics and Astronomy, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Shahinfard, Elham" sort="Shahinfard, Elham" uniqKey="Shahinfard E" first="Elham" last="Shahinfard">Elham Shahinfard</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physics and Astronomy, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physics and Astronomy, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Vafai, Nasim" sort="Vafai, Nasim" uniqKey="Vafai N" first="Nasim" last="Vafai">Nasim Vafai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physics and Astronomy, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physics and Astronomy, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Hasegawa, Kazuko" sort="Hasegawa, Kazuko" uniqKey="Hasegawa K" first="Kazuko" last="Hasegawa">Kazuko Hasegawa</name><affiliation wicri:level="1"><nlm:affiliation>Sagamihara National Hospital, Sagamihara, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Sagamihara National Hospital, Sagamihara</wicri:regionArea><wicri:noRegion>Sagamihara</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name><affiliation wicri:level="4"><nlm:affiliation>Veterans Affairs Puget Sound Health Care System and Department of Neurology, University of Washington, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Veterans Affairs Puget Sound Health Care System and Department of Neurology, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Mckenzie, Jessamyn" sort="Mckenzie, Jessamyn" uniqKey="Mckenzie J" first="Jessamyn" last="Mckenzie">Jessamyn Mckenzie</name><affiliation wicri:level="1"><nlm:affiliation>Pacific Parkinson's Research Centre, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Pacific Parkinson's Research Centre, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Neilson, Nicole" sort="Neilson, Nicole" uniqKey="Neilson N" first="Nicole" last="Neilson">Nicole Neilson</name><affiliation wicri:level="1"><nlm:affiliation>Pacific Parkinson's Research Centre, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Pacific Parkinson's Research Centre, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Strongosky, Audrey" sort="Strongosky, Audrey" uniqKey="Strongosky A" first="Audrey" last="Strongosky">Audrey Strongosky</name><affiliation wicri:level="2"><nlm:affiliation>Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J" last="Uitti">Ryan J. Uitti</name><affiliation wicri:level="2"><nlm:affiliation>Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Movement Disorders, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Movement Disorders, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P" last="Zabetian">Cyrus P. Zabetian</name><affiliation wicri:level="4"><nlm:affiliation>Veterans Affairs Puget Sound Health Care System and Department of Neurology, University of Washington, Seattle, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Veterans Affairs Puget Sound Health Care System and Department of Neurology, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Ding, Yu Shin" sort="Ding, Yu Shin" uniqKey="Ding Y" first="Yu-Shin" last="Ding">Yu-Shin Ding</name><affiliation wicri:level="2"><nlm:affiliation>New York University School of Medicine, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>New York University School of Medicine, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Adam, Mike" sort="Adam, Mike" uniqKey="Adam M" first="Mike" last="Adam">Mike Adam</name><affiliation wicri:level="1"><nlm:affiliation>TRIUMF, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>TRIUMF, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name><affiliation wicri:level="3"><nlm:affiliation>Norwegian University of Science and Technology, Trondheim, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Norwegian University of Science and Technology, Trondheim</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K" last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="2"><nlm:affiliation>Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Farrer, Matthew" sort="Farrer, Matthew" uniqKey="Farrer M" first="Matthew" last="Farrer">Matthew Farrer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Genetics, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Genetics, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Sossi, Vesna" sort="Sossi, Vesna" uniqKey="Sossi V" first="Vesna" last="Sossi">Vesna Sossi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physics and Astronomy, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physics and Astronomy, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A Jon" last="Stoessl">A Jon Stoessl</name><affiliation wicri:level="1"><nlm:affiliation>University of British Columbia, Department of Medicine, Vancouver, BC, Canada; Pacific Parkinson's Research Centre, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of British Columbia, Department of Medicine, Vancouver, BC, Canada; Pacific Parkinson's Research Centre, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Lancet. Neurology</title><idno type="eISSN">1474-4465</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain (metabolism)</term><term>Cross-Sectional Studies</term><term>Dihydroxyphenylalanine (analogs & derivatives)</term><term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term><term>Female</term><term>Heterozygote</term><term>Humans</term><term>Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 (genetics)</term><term>Male</term><term>Middle Aged</term><term>Mutation</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (metabolism)</term><term>Positron-Emission Tomography (methods)</term><term>Radiopharmaceuticals</term><term>Serotonin Plasma Membrane Transport Proteins (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Dihydroxyphenylalanine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Leucine-Rich Repeat Serine-Threonine Protein Kinase-2</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Parkinson Disease</term><term>Serotonin Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Positron-Emission Tomography</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cross-Sectional Studies</term><term>Female</term><term>Heterozygote</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mutation</term><term>Radiopharmaceuticals</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">People with Parkinson's disease can show premotor neurochemical changes in the dopaminergic and non-dopaminergic systems. Using PET, we assessed whether dopaminergic and serotonin transporter changes are similar in LRRK2 mutation carriers with Parkinson's disease and individuals with sporadic Parkinson's disease, and whether LRRK2 mutation carriers without motor symptoms show PET changes.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Inde</li><li>Japon</li><li>Norvège</li><li>États-Unis</li></country><region><li>Floride</li><li>Trøndelag</li><li>Washington (État)</li><li>État de New York</li></region><settlement><li>Seattle</li><li>Trondheim</li></settlement><orgName><li>Université de Washington</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Wile, Daryl J" sort="Wile, Daryl J" uniqKey="Wile D" first="Daryl J" last="Wile">Daryl J. Wile</name></noRegion><name sortKey="Adam, Mike" sort="Adam, Mike" uniqKey="Adam M" first="Mike" last="Adam">Mike Adam</name><name sortKey="Dinelle, Katherine" sort="Dinelle, Katherine" uniqKey="Dinelle K" first="Katherine" last="Dinelle">Katherine Dinelle</name><name sortKey="Farrer, Matthew" sort="Farrer, Matthew" uniqKey="Farrer M" first="Matthew" last="Farrer">Matthew Farrer</name><name sortKey="Guttman, Mark" sort="Guttman, Mark" uniqKey="Guttman M" first="Mark" last="Guttman">Mark Guttman</name><name sortKey="Mak, Edwin" sort="Mak, Edwin" uniqKey="Mak E" first="Edwin" last="Mak">Edwin Mak</name><name sortKey="Mckenzie, Jessamyn" sort="Mckenzie, Jessamyn" uniqKey="Mckenzie J" first="Jessamyn" last="Mckenzie">Jessamyn Mckenzie</name><name sortKey="Neilson, Nicole" sort="Neilson, Nicole" uniqKey="Neilson N" first="Nicole" last="Neilson">Nicole Neilson</name><name sortKey="Schulzer, Michael" sort="Schulzer, Michael" uniqKey="Schulzer M" first="Michael" last="Schulzer">Michael Schulzer</name><name sortKey="Shahinfard, Elham" sort="Shahinfard, Elham" uniqKey="Shahinfard E" first="Elham" last="Shahinfard">Elham Shahinfard</name><name sortKey="Sossi, Vesna" sort="Sossi, Vesna" uniqKey="Sossi V" first="Vesna" last="Sossi">Vesna Sossi</name><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A Jon" last="Stoessl">A Jon Stoessl</name><name sortKey="Vafai, Nasim" sort="Vafai, Nasim" uniqKey="Vafai N" first="Nasim" last="Vafai">Nasim Vafai</name></country><country name="Inde"><noRegion><name sortKey="Agarwal, Pankaj A" sort="Agarwal, Pankaj A" uniqKey="Agarwal P" first="Pankaj A" last="Agarwal">Pankaj A. Agarwal</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Hasegawa, Kazuko" sort="Hasegawa, Kazuko" uniqKey="Hasegawa K" first="Kazuko" last="Hasegawa">Kazuko Hasegawa</name></noRegion></country><country name="États-Unis"><region name="Washington (État)"><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name></region><name sortKey="Ding, Yu Shin" sort="Ding, Yu Shin" uniqKey="Ding Y" first="Yu-Shin" last="Ding">Yu-Shin Ding</name><name sortKey="Strongosky, Audrey" sort="Strongosky, Audrey" uniqKey="Strongosky A" first="Audrey" last="Strongosky">Audrey Strongosky</name><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J" last="Uitti">Ryan J. Uitti</name><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K" last="Wszolek">Zbigniew K. Wszolek</name><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P" last="Zabetian">Cyrus P. Zabetian</name></country><country name="Norvège"><region name="Trøndelag"><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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